What Should I Ask Aubrey de Grey?

Aubrey de Grey said yes.

For anyone who has not come across him, he is the biomedical gerontologist who has spent about twenty-five years arguing that aging is not a mystery to be solved but damage to be repaired. Break the damage into categories, fix each category, repeat before it accumulates again. He founded the SENS Research Foundation, and he now runs the Longevity Escape Velocity Foundation as its president and chief science officer.

He is also the person behind the phrase longevity escape velocity, which is the whole reason this project has the name it does. The idea is simple enough to explain in a sentence and strange enough to think about for years: if medicine starts adding more than a year of remaining life per year that passes, you stop losing ground. That is the bet I am making in public at 71.

Why Now Is an Interesting Moment to Talk to Him

His foundation has been running a large study called Robust Mouse Rejuvenation, testing whether combining several promising treatments in already middle-aged mice does more than any one of them alone. That first study has now finished, and by his own description the result was a qualified win rather than a clean one. A second study is being planned.

That is a more interesting conversation than a clean success would have been. I would rather hear what did not work and why.

Now Your Turn

Here is why I am posting this before the interview instead of after.

I get one shot at this and I would rather not waste it on the questions he has answered a hundred times. If you have been following this project, you are already thinking about this stuff. So tell me what you would ask.

Leave it in the comments, reply to the email if you are on the list, or post it in the Facebook group. I will read all of them, and I will take the good ones into the room with me.

One thing though: I am recording in two weeks, so get them to me before then. Editing takes a couple of weeks after that, so the video lands about a month from now — but the questions are only useful to me while I can still ask them.

If you would rather do this alongside other people than alone, I am opening ten seats in The 200 Year Life Mastermind — ten people, one year, live on Zoom, starting May 2027. Applications are open now.

Want to see the rest of what I do? Here is my full protocol list, my fitness routine, and every biomarker I track.

Stay sovereign, stay healthy.

I am not a physician and nothing here is medical advice. I am a guy running a long experiment on himself and showing his work.