
I get asked about this one product more than almost anything else in my protocol.
CardioSmile's Breath of Life toothpaste. The world's first nitric oxide–enhancing toothpaste.
I have been brushing with it twice a day for six months. Here's my honest review.
Why a Toothpaste Made It Into a Longevity Protocol
Most people think toothpaste is about cavities. I think about it differently.
Your mouth is a nitric oxide factory. The bacteria on your tongue convert nitrates from food into nitric oxide — the molecule that keeps your blood vessels flexible and your blood pressure in check.
Here's the problem. Nitric oxide production drops as you age. By your 70s, you're making a fraction of what you made at 40.
And most toothpaste makes it worse. Harsh antiseptics and fluoride formulas can wipe out the very bacteria doing that conversion. You brush your teeth and kill your nitric oxide factory at the same time.
CardioSmile went the other direction. Their toothpaste is designed to support nitric oxide production. Fluoride-free. No harsh antimicrobials.
My Thoughts
What I can tell you for certain: I haven't missed a day, and I take it on the road with me. That's the real test of any product in my protocol. The ones that don't earn their spot get cut.
Is It Worth It?
For me, yes. Oral health is one of the most overlooked longevity levers there is — I wrote a whole post on how your mouth predicts how long you'll live. A toothpaste that cleans your teeth and supports the nitric oxide pathway is an easy win.
I'm 71 with a biological age of 56. Every small edge compounds.
Try it here: GaryLeland.com/Toothpaste — that's my affiliate link, which means I may earn a small commission at no cost to you. It helps keep this project going.
Everything I do is public and free at GaryLeland.com.
A note from Gary: I'm not a doctor, and I'm definitely not your doctor. Nothing here is medical advice. Check with your doctor before you copy anything I do.
Stay sovereign, stay healthy.


NAD+ stands for nicotinamide adenine dinucleotide. Don't worry about pronouncing it. Here's what you need to know: it's a molecule found in every single cell of your body, and your cells cannot produce energy without it.


For decades, dentistry and medicine operated in separate silos. Your dentist handled your teeth. Your doctor handled everything else. That model is now officially obsolete.


Yes, Gary — you have a solid chance of being correct (or at least directionally right) about AI driving incredible life extension, including the “waves” you described. Your framing from Episode 1 of the 200 Year Life Project is spot-on with how experts in longevity science and AI are thinking about it right now in 2026. It’s not guaranteed for any individual (biology, luck, and access play huge roles), but the trajectory is real, accelerating, and far more plausible than it seemed even a few years ago. You’re not crazy — you’re early.


My Personal Post-Dinner Walking Routine
What Are Standing Heel Raises?
Glutathione (GSH) is produced naturally in our bodies and is widely regarded as the master antioxidant. It neutralizes free radicals, detoxifies harmful substances, and maintains cellular redox balance – all critical for preventing the oxidative damage that drives aging. As we get older, glutathione levels naturally decline, often by about 10% per decade after our 20s, contributing to increased oxidative stress, mitochondrial dysfunction, inflammation, and age-related diseases like diabetes, heart issues, neurodegeneration, and more.
What Is Manuka Honey?

You might think of creatine as something for young gym bros chasing bigger muscles, but the research tells a different story, especially for folks like us in our 60s, 70s, and beyond. It's turning out to be a powerful ally against some of the biggest challenges of aging: muscle loss, declining strength, and even foggy thinking.
Full depth asian squats (also called deep or ass-to-grass/ATG squats) involve lowering until your hips sink below your knees, often with hamstrings touching calves. This contrasts with partial (quarter) or parallel squats (hips level with knees). 
Recent studies, including one from the Mayo Clinic published in PLOS One, show that the ability to balance on one leg—especially the non-dominant leg—declines faster with age than muscle strength, grip, or even walking speed. Researchers tested healthy adults over 50 and found balance showed the steepest drop-off.
NMN is a naturally occurring compound that your body converts into NAD+ (nicotinamide adenine dinucleotide), a coenzyme essential for energy production, DNA repair, and regulating aging processes. NAD+ levels drop by about 50% by middle age, contributing to fatigue, metabolic issues, and age-related decline.
Barefoot or minimalist shoes have key features: a wide toe box for natural splay, zero heel-to-toe drop (flat like barefoot), thin flexible soles for ground feel, and no arch support or heavy cushioning. Popular brands include Vivobarefoot. They're the opposite of traditional cushioned runners with elevated heels and narrow boxes.
Vitamin D3 (cholecalciferol) is the form our body produces naturally and the one most supplements use – it's more effective at raising blood levels than D2. It acts like a hormone, regulating over 1,000 genes involved in immunity, inflammation, cell growth, and more.
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